Holoprosencephaly (HPE)


Level II Ultrasound.
Hands and technical skills are mandatory.
Moderate learning curve.

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Holoprosencephaly (HPE)

In this 28 slides ultrasound lecture you will learn:

  • Definition of Holoprosencephaly (HPE).
  • Embryologic Basis of HPE.
  • Sequence of Interference with the Activity of the Prechordal Mesenchyme.
  • Classification of HPE.
    • According to the degree of failure of cleavage of prosencephalon.
    • According to the degree of failure of inward rotation of the primitive cerebral hemispheres.
  • Ultrasound Diagnosis of HPE.
    • Intracranial Criteria.
    • Cranial Criteria.
    • Facial Criteria.


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